Selective Serotonin Reuptake Inhibitors (SSRIs)

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Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressant medications for easing mood/anxiety symptoms. They work by increasing the neurotransmitter serotonin levels in the brain by blocking its reabsorption (reuptake) into neurons. More serotonin improves message transmission across neurons. SSRIs are selective because they affect serotonin, not other neurotransmitters. They’re relatively safe and typically cause fewer side effects than other classes of antidepressants. In addition to treating anxiety and depression, they’re commonly prescribed for OCD, panic disorder, and social phobia. SSRIs are:

  • Citalopram (Celexa)
  • Escitalopram (Lexapro)
  • Fluoxetine (Prozac)
  • Paroxetine (Paxil, Pexeva)
  • Sertraline (Zoloft)
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