Second-Generation, Atypical Antipsychotics (SGAs)

Second-generation, atypical antipsychotics (SGAs) work like lithium — reducing excitatory neurotransmitter release, blocking dopamine sites, and increasing inhibitory neurotransmitter release. SGAs, like aripiprazole, can treat both mania and depression but are mostly prescribed if someone experiences psychotic symptoms during a manic episode.