Neuronal Death:

Neuronal death, happens even though neurons are the longest living cells in the body. Large numbers of them die during migration and differentiation. Even with solid evidence of neurogenesis, new adult neuronal growth is limited — and neuronal death has severe consequences. Some brain diseases result from unnatural deaths of neurons (like Parkinson’s, Alzheimer’s, or strokes), brain injury (accidents, contact sports), or severe mental illness (SMI), like bipolar disorder. Research has shown there are more than 12 ways for neurons to die, that blocking mechanisms of cell death may not prevent the cell from dying, and that non-neuronal cells also contribute to neuronal death.