Dopamine Signaling

Dopamine signaling is the process by which the neurotransmitter dopamine binds to sensory receptors on neurons and generates/transmits information to neighboring neurons. When a person engages in enjoyable activities, dopamine-producing neurons in the midbrain release dopamine into the synaptic cleft (space between neurons). The stimulation of the dopamine receptors is believed to produce pleasurable feelings or rewarding effects. Dopamine signaling is key to many physiological processes, including: motor control, motivation and reward, cognitive function, and maternal and reproductive behaviors. Changes in dopamine signaling are closely associated with drug addiction and obesity. Drugs produce large surges of dopamine, reinforcing the drug-pleasure connection.